I/O errors could be caused by several areas could you check for the following:

1) If running in a Bond Mode try disabling this and test with out it. Remember when disabling the Bond it will default to the original IP Address

2) Try a different port on the Switch or use a crossover cable.

3) Check the RAID controller logs

4) Check memory - restart system and after POST hit the escape key to access a menu then select memory test.

5) Disable any Snapshots, Synchronizations, Antivirus and Backups

6) Please use this tool to check system status ip address of server x.x.x.x/check_sys/127.0.0.1.html check free memory.

7) Check drive status in controller or S.M.A.R.T (will not work with Hardware RAID controller).

If none of these are able to identify the problem then send logs to support@open-e.com.