Prior to build 3216 we experienced difficulties when rebooting the DSS (all FC-attached initiators had to be disconnected during reboot, else no target could be seen afterwards - it was sufficient if the connected servers were powered on), but this seems to be fixed with build 3216 (though we have not excessively tested this - we try to avoid rebooting the DSS while initiators are active ;-) ).
We see no operational problems so far. We use only target mode, with two directly connected FC initiators, one per port.