Hello, you could enable MPIO support in ESXi (I use ESXi 4) and enabling MPIO allows the traffic to be round-robin load balanced across multiple connections between open-e and your vmware server. This was something like a 4 click operation, once you had already assigned a VMKernel port and IP to the adapter on ESXi.

There are some very good how-to's in the support/documentation section of the open-e website.

Hope this helps,

TFZ