I'm running the 3513 build of DSS. I have two servers which I run DSS on, each server has 3 RAID configs and I map their LUNs to a single target. I have, on each server, different RAID setups ranging from RAID1, RAID5, RAID 10.
I also run these targets through a 10GbE Network, so maybe this is why I never ran into timeouts, are you using a similar setup?
On ESX3.5u3 I was not getting this same issue... however, I was experiencing finicky connection drops due to the use of the NetXen 10GbE NICs in my systems.
This weekend I will be installing Intel 2xCX4 10GbE NICs in my machines to alleviate that problem.