Dear Anashel;
Depending on your infrastructure it should be very robust. OpenE and VMWare work very well together. What are you using for targets? FC or iSCSI? If the VMware best practices are followed you should have no troubles like you have described. We have many customers with your configuration, using Open-e for the management software and our mix of best-of-breed components for the hardware. If you want, you can email us (my company) at: stelter@massmountain.com or just get back to me in this forum.