I have a similar setup I guess you could say.
I have 2 x 8TB Open-E servers (custom built hardware, supermicro mainboard, 3ware raid card, intel nics) in isci failover setup.
I have 8 VM Hosts (ESXi 4.1) with around 60VM guests spread across these hosts (all in a VM Cluster with EVC).
Apart from some teething issues, bad hardware mainly/learning curve the others .
DSS V6 has run pretty much perfectly.
I have 6 nic's in my Open-E serves with 4 of them allocated to the iSCSI network (MPIO) via dedicated switches (I have 2 switches for the iSCSI traffic, and 2 for my inet traffic). This is all to handle any failures. 1 of the nic's is direct connected to the other SAN for replication traffic, and the last nic is for management.
DSS is very capable and is VMWare friendly.
Maybe post up more of your configuration and issues you have had?
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