Todd,
What is the best configuration with 2 nodes and 4 cards each?
I thought:

DSS01:
eth0: 192.168.0.1 -> Management
eth1: 192.168.1.1 -> iSCSI1 - Failover (Virtual IP 10.0.0.1)
eth2: 192.168.2.1 -> iSCSI2 - Failover (Virtual IP 10.0.0.2)
eth3: 192.168.3.1 -> Heartbeat

DSS02:
eth0: 192.168.0.2 -> Management
eth1: 192.168.1.2 -> iSCSI1 - Failover (Virtual IP 10.0.0.1)
eth2: 192.168.2.2 -> iSCSI2 - Failover (Virtual IP 10.0.0.2)
eth3: 192.168.3.2 -> Heartbeat

ESX iSCSI:

Connect with 2 vmkernel to 2 iSCSI IP for redudancy -> 10.0.0.1 e 10.0.0.2

What do you think?

thanks!