I was able to get to 4362 by removing all ESX Volumes, Deleting all Volumes from Volume Groups in DSSv6, recreating all volumes as Block I/O instead of File I/O and then representing those to ESX4.

I then upgraded from 4221 to 4362 and the volumes are still present and LUNs still connecting to ESX.

I will try to 4452 upgrade now and post the results.