When I upgraded to build 4622, I had major Active Directory security problems with my SMB shares. Most of the time, it wouldn't accept my SMB login cradentials. In many cases, it would work on one DSS network interface, but not on another interface. By repeatedly reconfiguring the DSS domain settings, it would sometimes start working with the second interface, but then stop working on the first interface.

When I reverted back to build 4550, everything went back to normal.

My domain server is running Server 2003.