MPIO needs only 2 NIC (our 4 if you are bonding) and VIP to be set for each then select which Primary Node NIC that you wish to use or the 10.x.x.x NIC.

Details on how this is done from the link below.
http://www.open-e.com/library/how-to-resources/

# 2010.12 How to configure DSS V6 MPIO with Windows 2008 Server
# 2010.12 Open-E DSS V6 MPIO with ESXi 4.x