Hmm your using a desktop adapter for your MPIO I would carefully check your specs on these adapters. Not saying there is an issue here, just I wouldn't use desktop cards for anything intensive and iSCSI MPIO, the rest of your esxi settings look right.
What is your switch equipment? Have you check packet through put on your switches etc
1. From the console, press CTRL+ALT+W,
2. Select Tuning options -> iSCSI daemon options -> Target options,
3. Select the target in question,
4. change the MaxRecvDataSegmentLength and MaxXmitDataSegmentLength values to the
maximal required data size (check w/ the initiator to match).