Single 8 disks will give you more flexible way to deal with space, and disks, while using 2 of 4 disks will let you maybe more organized with your data, as if you want to add extra space to a the NAS or iSCSI users you have.
The easiest way now a day to save a backup for all the system is to have an external HDD and save a backup on it, that way you will be in double safe.
Thanks a lot for your input!
I now decided to start with two sets of 4 disks each.
The most interesting point for me is:
What do you think, how the speed will change?
Especially the IO-speed of the iSCSI volume, which should host some VMs for ESX in the future.
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