Yes, in fact this is the preferred method. We have documents and videos on how to setup this with MPIO for the DSS V6 and the ESX server. See below.

http://documents.open-e.com/Open-E_D..._ESX4i_4.1.pdf

http://www.open-e.com/service-and-su...ts-and-videos/
2010.12.14 Open-E DSS V6 MPIO mit VMware ESXi 4.1 und Windows 2008