ESX 4.1 loses iSCSI connection after reboot

[To-M]

Also you might want to try to tune your Targets as well.

1. From the console, press CTRL+ALT+W,

2. Select Tuning options -> iSCSI daemon options -> Target options,

3. Select the target in question,

4. change the MaxRecvDataSegmentLength and MaxXmitDataSegmentLength values to
the maximal required data size (check w/ the initiator to match).

maxRecvDataSegmentLen=262144
MaxBurstLength=16776192
Maxxmitdatasegment=262144
FirstBurstLength=65536
DataDigest=None
maxoutstandingr2t=8 InitialR2T=No
ImmediateData=Yes
headerDigest=None
(deprecated)Wthreads=8

Doing this will reset the iSCSI connections at each edit. Please pause any hosts connected
to the LUNS. These adjustments need to be made at each node, and at the initiators.

Did you look at this document - keep in mind that ESX 4.x MPIO is different then 5.0 and .51.
http://www.open-e.com/site_media/dow..._ESX4i_4.1.pdf