Try with MPIO with 2 NICs on the DSS side and your 2 dedicated vmkernel NICs. Your correct on keeping the jumbo frames the default. Also try to make these changes on the DSS side but stop the VM's and reconnect from the ESX once you make these changes.
1. From the console, press CTRL+ALT+W,
2. Select Tuning options -> iSCSI daemon options -> Target options,
3. Select the target in question,
4. change the values to the maximum required data size (check w/ the initiator to match).
Doing this will reset the iSCSI connections at each edit. Please pause any hosts connected
to the LUNS. These adjustments need to be made at each node if in failover configuration, and at the initiators.
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