Hello Todd,
I use MPIO for the VIP NICs - I only use a balance-rr Bond for the Storage Replication NICs:

4 NICs with VIPs presenting iSCSI -- VMware/Win2008 connected with MPIO
3 NICs as balance-rr bond for Storage Replication -- all cables connected directly 1:1 without a Switch inbetween.


About your iSCSI Target Options: At the moment we're running ESX4 but we're planning the upgrade to V5.x. Are these settings optimized for VMware in general?



Hello Alex,
yes I use the Open-E only as a big box, same iSCSI configuration on each side.



Thank you.
Bye, Manuel