This is the point of my question:

Is it recomended to adjust target settings to initiator defaults?

Default iSCSI settings are different between VMWare, Server2008 and DSS7
(can't find recomended maxoutstandingr2t=? for Win).
Can you recomend propriate settings on DSS console for WinServer2008R2, for example?

Is performance better, if all targets&initiators use equally settings?

Thank you for the answer!
Toni