There is a thread going on the VMware forums where someone else is running into having to keep the LUN numbers globally unique with Open-E. There are a few responses there pointing back to the iSCSI Enterprise Target mailing list
which points towards a possible config in iSCSI Enterprise Target (which I believe is the base open source package for Open-E) where the SCSI_SN needs to be unique per target/volume or else the LUN# itself needs to be kept globally unique. So a question would be is in Open-E iSCSI are all the SCSI_SNs set to the same value (or not set at all) or are they unique per target/volume (i.e. the "equivalent" of a SCSI disk once presented to the OS)?