We use our open-s DSS a server as primary storage for SQL, Exchange and VMware and also a secondary open-e DSS which is replicated from the primary storage.
We have tested using iscsi the speeds where good (140MBs) but the problem with using sql and exchange is that you need to make sure to delay the starting of the services if the servers are rebooted not too difficult by using a batch file with a ping command to provide the timeout value. Also you cannot use dynamic disks with the microsoft iscsi initator as on reboot the drives sometimes do not come back online, so use them as basic disks (know bug with microsoft)
You can use dynamic disks if you use a third party iscsi initiator such as starwind, but agin serices will need to be delayed. Advantages would be that you could extend/mirror dynamic disks.
Ths best solution we found was using fibre channel 2GB as it addresses all the issues and speeds for combined read/write of 270Mbs, we are busy testing the 4GB and so far average speeds of 570Mb/s
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